Mass disasters, particularly earthquakes, can cause many immediate and long-term health impacts on human beings. Trauma-related injuries and deaths from building collapse, or from the secondary effects of the earthquake are most commonly reported. Other complications such as dehydration, inflammation, malnutrition, crush injury-induced acute kidney injury (AKI), sepsis, and multiple organ failure following earthquakes have also been reported. ^[1][2]

Studies have focused on blood purification for the treatment of severe or critical trauma-related injuries. In particular, hemoperfusion therapy is becoming common in recent years.

What is Hemoperfusion therapy?

Hemoperfusion is one of the blood purification therapy based on hemoadsorption technology, using sorbent materials with high adsorptive properties to clean toxins, drugs, and metabolites from the blood.^[5] It contains a series of perfusion machines and adsorbing cartridges, like the HA series cartridge. Today we are going to introduce more about this HA380 for critical diseases.

HA380 disposable hemoperfusion cartridge is filled with neutral macroporous resin with a target range of molecules from 10k to 60 kDa. The molecules are attracted by the huge adsorptive surface through accurate 3D macroporous structure, hydrophobicity, and van der Waals interaction when the blood circulates contact with it. During hemoperfusion treatment, the target middle to large molecules, protein-bound toxins, and inflammatory mediators such as CRP, PCT, IL-6, IL-8, and IL-10 could be removed from the blood by being bound to the adsorptive surface without safety concerns.^[6]

Why choosing HA380?

According to clinical practices, HA380 can be applied in patients with sepsis, septic shock, traumatic injuries, cardiac surgeries, severe acute pancreatitis (SAP), burn, Covid-19, acute respiratory distress syndromes (ARDS), as well as other hyperinflammatory conditions. ^[5][7-10] A research found that the levels of inflammatory markers, C-reactive protein (CRP), and proinflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were significantly higher in the group of patients who had crush syndrome with AKI after earthquake compared to healthy adults.^[4] These patients can benefit from HA380 hemoperfusion therapy because it effectively controls the inflammatory cytokines storms, improving hemodynamics, preventing further organ failure and complications, as well as shortening the ICU and hospital stay.^[5][7-10]   

What’s the operation modes of HA380 Hemoperfusion therapy?

HA380 hemoperfusion cartridge can be used alone or in conjunction with other blood purification methods such as continuous renal replacement therapy (CRRT), hemodialysis (HD) or hemodiafiltration (HDF). A study has reported a successful resuscitation experience of using multiple-mode hybrid treatment including high-volume hemofiltration, low-temperature blood purification, hemoperfusion, and plasmapheresis for a patient with severe crush syndrome induced AKI and MODS.^[3] Therefore, the combination therapy of hemoperfusion with other modes of blood purification method would be more effective in the treatment of critically ill patients.

In summary, HA380 hemoperfusion therapy is a promising treatment that can provide a new regimen for treating patients with severe crush-syndrome related medical complications such as AKI, sepsis, MODS, and so on.

References

[1] Would Health Organisation (WHO). Earthquakes: impact. Accessed February 15, 2023. https://www.who.int/health-topics/earthquakes#tab=tab_2

[2] Ramesh G, Reeves WB. Inflammatory cytokines in acute renal failure. Kidney Int Suppl. 2004;(91):S56-S61. doi:10.1111/j.1523-1755.2004.09109.x

[3] Wei Q, Baihai S, Ping F, Xiaolei C, Jing L, Rong Z. Successful treatment of crush syndrome complicated with multiple organ dysfunction syndrome using hybrid continuous renal replacement therapy. Blood Purif. 2009;28(3):175-180. doi:10.1159/000227786

[4] Li GS, Chen XL, Zhang Y, et al. Malnutrition and inflammation in acute kidney injury due to earthquake-related crush syndrome. BMC Nephrol. 2010;11:4. Published 2010 Mar 27. doi:10.1186/1471-2369-11-4

[5] Chu L, Li G, Yu Y, Bao X, Wei H, Hu M. Clinical effects of hemoperfusion combined with pulse high-volume hemofiltration on septic shock. Medicine (Baltimore). 2020;99(9):e19058. doi:10.1097/MD.0000000000019058

[6] Pomarè Montin D, Ankawi G, Lorenzin A, Neri M, Caprara C, Ronco C. Biocompatibility and Cytotoxic Evaluation of New Sorbent Cartridges for Blood Hemoperfusion. Blood Purif. 2018;46(3):187-195. doi:10.1159/000489921

[7] Clark WR, Ferrari F, La Manna G, Ronco C. Extracorporeal Sorbent Technologies: Basic Concepts and Clinical Application. Contrib Nephrol. 2017;190:43-57. doi:10.1159/000468911

[8] Shadvar K, Tagizadiyeh A, Gamari AA, Soleimanpour H, Mahmoodpoor A. Hemoperfusion as a Potential Treatment for Critically Ill COVID-19 Patients with Cytokine Storm. Blood Purif. 2021;50(3):405-407. doi:10.1159/000511391

[9] He Z, Lu H, Jian X, et al. The Efficacy of Resin Hemoperfusion Cartridge on Inflammatory Responses during Adult Cardiopulmonary Bypass. Blood Purif. 2022;51(1):31-37. doi:10.1159/000514149

[10] Gong M, Pan H, Yang X, Pan C, Ning Y, Li J. Prolonged Intermittent Renal Replacement Therapy Combined with Hemoperfusion Can Improve Early Recovery of Moderate and Severe Acute Pancreatitis, Especially in Patients with Acute Kidney Injury. Blood Purif. 2023;52(1):75-85. doi:10.1159/000525230